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Check Intently (3)pentobarbital will reduce the extent or impact of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid or reasonable CYP3A4 inducers may perhaps raise charge of diazepam elimination; therefore, efficacy of diazepam may very well be lowered.pentobarbital will lower the level or outc